Recently, there has been extensive research interest in training deep networks to denoise images without clean reference. However, the representative approaches such as Noise2Noise, Noise2Void, Stein's unbiased risk estimator (SURE), etc. seem to differ from one another and it is difficult to find the coherent mathematical structure. To address this, here we present a novel approach, called Noise2Score, which reveals a missing link in order to unite these seemingly different approaches. Specifically, we show that image denoising problems without clean images can be addressed by finding the mode of the posterior distribution and that the Tweedie's formula offers an explicit solution through the score function (i.e. the gradient of loglikelihood). Our method then uses the recent finding that the score function can be stably estimated from the noisy images using the amortized residual denoising autoencoder, the method of which is closely related to Noise2Noise or Nose2Void. Our Noise2Score approach is so universal that the same network training can be used to remove noises from images that are corrupted by any exponential family distributions and noise parameters. Using extensive experiments with Gaussian, Poisson, and Gamma noises, we show that Noise2Score significantly outperforms the state-of-the-art self-supervised denoising methods in the benchmark data set such as (C)BSD68, Set12, and Kodak, etc.

UOTA adaptively searches for the most important sampling region to produce views, and provides viable choice for outlier-robust self-supervised learning approaches.

Here, we develop a novel learning rule designed to minimize interferencebetween sequentially learned tasksinrecurrent networks.

Traditional multi-label learning studies focus on closed set scenario.

The electrocardiogram (ECG) is an essential and effective tool for diagnosing heart diseases. However, its effectiveness can be compromised by noise or unavailability of one or more leads of the standard 12-lead recordings, resulting in diagnostic errors or uncertainty. To address these challenges, we propose TolerantECG, a foundation model for ECG signals that is robust to noise and capable of functioning with arbitrary subsets of the standard 12-lead ECG. TolerantECG training combines contrastive and self-supervised learning frameworks to jointly learn ECG signal representations alongside their corresponding knowledge-retrieval-based text report descriptions and corrupted or lead-missing signals. Comprehensive benchmarking results demonstrate that TolerantECG consistently ranks as the best or second-best performer across various ECG signal conditions and class levels in the PTB-XL dataset, and achieves the highest performance on the MIT-BIH Arrhythmia Database.

Sarcopenia is a progressive loss of muscle mass and function linked to poor surgical outcomes such as prolonged hospital stays, impaired mobility, and increased mortality. Although it can be assessed through cross-sectional imaging by measuring skeletal muscle area (SMA), the process is time-consuming and adds to clinical workloads, limiting timely detection and management; however, this process could become more efficient and scalable with the assistance of artificial intelligence applications. This paper presents high-quality three-dimensional cross-sectional computed tomography (CT) images of patients with sarcopenia collected at the Freeman Hospital, Newcastle upon Tyne Hospitals NHS Foundation Trust. Expert clinicians manually annotated the SMA at the third lumbar vertebra, generating precise segmentation masks. We develop deep-learning models to measure SMA in CT images and automate this task. Our methodology employed transfer learning and self-supervised learning approaches using labelled and unlabeled CT scan datasets. While we developed qualitative assessment models for detecting sarcopenia, we observed that the quantitative assessment of SMA is more precise and informative. This approach also mitigates the issue of class imbalance and limited data availability. Our model predicted the SMA, on average, with an error of +-3 percentage points against the manually measured SMA. The average dice similarity coefficient of the predicted masks was 93%. Our results, therefore, show a pathway to full automation of sarcopenia assessment and detection.